1-Fluoronaphthalene → 4-[4-(Naphthoxy)piperidinyl]-2-phenylquinazoline

HRID 1659958Notes

Reaction equation

HRID 1659958 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=2)[CH2:4][CH2:3]1.[H-].[Na+].F[C:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1>CN(C)C=O>[C:35]1([O:1][CH:2]2[CH2:7][CH2:6][N:5]([C:8]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]=[C:10]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[N:9]=3)[CH2:4][CH2:3]2)[C:36]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:32]=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 94501-FluoronaphthaleneHCID 24758Sodium hydrideHCID 127960301-(2-Phenyl-4-quinazolinyl)-4-piperidinol

Product 1

HCID 205064704-[4-(Naphthoxy)piperidinyl]-2-phenylquinazoline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Equimolar quantities of 4-(4-hydroxypiperidinyl)-2-phenylquinazoline, sodium hydride and 1-fluoronaphthalene are heated in dimethylformamide to prepare the title compound.

Sources & evidence

ORD record
ord-904950ade9ad4daea1188e1cb8c122f5
Source dataset
uspto-grants-1981_12
Patent number
US04306065

Reaction notes

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