5-Aminopentan-1-ol → HCID 20558843, compound

HRID 1659966Notes

Reaction equation

HRID 1659966 reaction equation
CS([O-])(=O)=O.[C:6]1(=[O:13])[O:12][C:10](=[O:11])[CH2:9][O:8][CH2:7]1.[NH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][OH:20]>>[OH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:14][C:10](=[O:11])[CH2:9][O:8][CH2:7][C:6]([OH:12])=[O:13]

Participants

4

Reactant 3

HCID 756345-Aminopentan-1-olHCID 782321,4-Dioxane-2,6-dioneHCID 85257Methanesulfonate

Product 1

HCID 20558843HCID 20558843, compound

Procedure

methanesulfonate by the following sequence of steps: (a) by reacting diglycolic anhydride and 5-aminopentanol to produce [2-(5-hydroxypentyl)amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(5-hydroxypentyl)-b 3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 5-(3,5-dioxomorpholino)pentyl methanesulfonate and (d) reacting the mesylate with 2-benzhydrylpiperidine.

Sources & evidence

ORD record
ord-3e72aa36157247d6b12172d3c5a542eb
Source dataset
uspto-grants-1981_12
Patent number
US04306063

Reaction notes

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