Hydrochloric Acid → HCID 20496918, compound

HRID 1660060Notes

Reaction equation

HRID 1660060 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[CH:17]1[CH2:22][CH2:21][CH2:20][C:19](=[O:23])[CH2:18]1.[C:24](OC(=O)C)(=[O:26])[CH3:25].Cl>N1C=CC=CC=1>[C:24]([O:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[CH:17]1[CH2:22][CH2:21][CH2:20][C:19](=[O:23])[CH2:18]1)(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 127881913-[2-Hydroxy-4-(2-methyloctan-2-yl)phenyl]cyclohexan-1-one

Product 1

HCID 20496918HCID 20496918, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 2.0 g of 3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]cyclohexanone in 15 ml of pyridine is treated at 10° C. with 10 ml acetic anhydride and the mixture stirred for 18 hours under nitrogen. It is then poured onto ice/water and acidified with dilute hydrochloric acid. The acidified mixture is extracted with ethyl acetate (2×100 ml), the extracts combined, washed with brine and dried (MgSO4). Evaporation under reduced pressure give the title product as an oil.

Workup

  1. additionIt is then poured onto ice/water
  2. extractionThe acidified mixture is extracted with ethyl acetate (2×100 ml)
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. customEvaporation under reduced pressure

Sources & evidence

ORD record
ord-0ae327eb084544fc9b592ff9bc1a1337
Source dataset
uspto-grants-1981_12
Patent number
US04306097

Reaction notes

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