trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]-5-methylcyclohexanone → trans-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-5-methyl-cyclohexanone

HRID 1660066ノート

反応式

HRID 1660066 の反応式
C([O:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:23])([CH3:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:12]=[CH:11][C:10]=1[C@H:24]1[CH2:29][C@H:28]([CH3:30])[CH2:27][C:26](=[O:31])[CH2:25]1)C1C=CC=CC=1.[H][H]>[Pd].CO>[CH3:23][C:15]([C:13]1[CH:12]=[CH:11][C:10]([C@H:24]2[CH2:29][C@H:28]([CH3:30])[CH2:27][C:26](=[O:31])[CH2:25]2)=[C:9]([OH:8])[CH:14]=1)([CH3:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

参加物

5

反応物 2

HCID 70529131trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]-5-methylcyclohexanoneHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 70530367trans-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-5-methyl-cyclohexanone収率 64.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of trans-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-5-methylcyclohexanone (175 mg, 0.417 mmole) and 175 mg of 5% palladium on carbon-50% water in methanol (8 ml) was stirred under one atmosphere of hydrogen gas until hydrogen uptake ceased. The reaction mixture was filtered through diatomaceous earth and the filtrate evaporated under reduced pressure. Crystallization of the residue in pentane gave 89 mg (64%) of the title compound.

後処理

  1. filtrationThe reaction mixture was filtered through diatomaceous earth
  2. customthe filtrate evaporated under reduced pressure
  3. customCrystallization of the residue in pentane

出典と根拠

ORDレコード
ord-b71aa945531446ee8485959bfd829f13
出典データセット
uspto-grants-1981_12
特許番号
US04306097

反応ノート

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