Hydrochloric Acid → HCID 13144524, compound

Participants

Reaction Steps

Methyl 5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-propionate was dissolved in methanol and the solution was stirred at room temperature for 2 hours with 1-M sodium hydroxide solution (1.1 mol equivalents). The mixture was acidified with concentrated hydrochloric acid and then evaporated to dryness. The residue was extracted with acetonitrile and the extracts were evaporated to give 5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-propionic acid of melting point 172°-175° C. (from acetonitrile).

Provenance & Evidence