Hydrochloric Acid → HCID 13144524, compound

HRID 1660136Notes

Reaction equation

HRID 1660136 reaction equation
[C:1]([CH:4]1[CH:9]=[CH:8][CH2:7][N:6]2[C:10](=[O:20])[N:11]([CH2:14][CH2:15][C:16]([O:18]C)=[O:17])[C:12](=[O:13])[N:5]12)([OH:3])=[O:2].[OH-].[Na+].Cl>CO>[C:1]([CH:4]1[CH:9]=[CH:8][CH2:7][N:6]2[C:10](=[O:20])[N:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:12](=[O:13])[N:5]12)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20557538HCID 20557538, compound

Product 1

HCID 13144524HCID 13144524, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-propionate was dissolved in methanol and the solution was stirred at room temperature for 2 hours with 1-M sodium hydroxide solution (1.1 mol equivalents). The mixture was acidified with concentrated hydrochloric acid and then evaporated to dryness. The residue was extracted with acetonitrile and the extracts were evaporated to give 5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-propionic acid of melting point 172°-175° C. (from acetonitrile).

Workup

  1. customevaporated to dryness
  2. extractionThe residue was extracted with acetonitrile
  3. customthe extracts were evaporated

Sources & evidence

ORD record
ord-626843e079d541128989d25821bffc9d
Source dataset
uspto-grants-1981_12
Patent number
US04307094

Reaction notes

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