2,4-Difluoroaniline → HCID 13093903, compound

HRID 1660167Notes

Reaction equation

HRID 1660167 reaction equation
[C:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:8]=1)#[N:2].FC1C=C(F)C=CC=1N.[Cl:28][C:29]([Cl:33])([Cl:32])[S:30]Cl>>[C:1]([C:3]1[C:4](=[O:18])[N:5]([S:30][C:29]([Cl:33])([Cl:32])[Cl:28])[C:6](=[O:17])[N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:8]=1)#[N:2]

Participants

4

Reactant 3

HCID 97092,4-DifluoroanilineHCID 11666Trichloromethanesulfenyl chlorideHCID 2821946HCID 2821946, compound

Product 1

HCID 13093903HCID 13093903, compound

Procedure

In like manner, 5-cyano-1-(2,4-difluorophenyl)uracil is prepared, starting with 2,4-difluoroaniline, and is then reacted with trichloromethanesulphenyl chloride, giving 5-cyano-1-(2,4-difluorophenyl)-3-trichloromethanesulphenyluracil, m.p. 196°-198°.

Sources & evidence

ORD record
ord-dfaee125c6a54472baab65bafd2e2ce8
Source dataset
uspto-grants-1981_12
Patent number
US04307098

Reaction notes

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