Hydrogen Bromide → HCID 178419247, compound

HRID 1660183Notes

Reaction equation

HRID 1660183 reaction equation
Cl.O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14].[BrH:15]>C(O)(=O)C>[BrH:15].[BrH:15].[CH3:9][C:8]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 9082Cysteamine HydrochlorideHCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

Product 1

HCID 178419247HCID 178419247, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4-hydroxymethyl-5-methylimidazole hydrochloride (15.0 g.), cysteamine hydrochloride (11.5 g.) and a solution of hydrogen bromide in acetic acid (48%, 225 ml.) was heated under reflux for 7 hours. Cooling afforded 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (21.6 g.), m.p. 208°-211°.

Workup

  1. temperatureunder reflux for 7 hours
  2. temperatureCooling

Sources & evidence

ORD record
ord-b7f298150b0a46ecb0cd5e1b5b490b5d
Source dataset
uspto-grants-1981_12
Patent number
US04307101

Reaction notes

Loading…