1,3-Propanediamine → 2-(3-Aminopropylamino)pyrazine

HRID 1660220Notes

Reaction equation

Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12]>>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 4281,3-Propanediamine

HCID 73277Chloropyrazine

Product 1

HCID 143974072-(3-Aminopropylamino)pyrazine

Procedure

Reacting 2-chloropyrazine with 1,3-diaminopropane by the procedure of Example 93 gives 2-(3-aminopropylamino)pyrazine and reacting this intermediate with methyl isothiocyanate gives the title compound.

Sources & evidence

ORD record: ord-a4b25f0d171244f2a8db1cc10112c92c
Source dataset: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04307101

Reaction notes

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