HCID 20485093, compound → HCID 12786428, compound
Reaction equation
C([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[N:10]1[C:12]([CH3:17])=[N:13][CH:14]=[C:15]([CH3:16])[C:9]1=[C:8]2[CH2:18][CH2:19][N:20]([CH3:24])[CH:21]([CH3:23])C)C.[CH2:25](C1C2=C(CCN(C)C(C)C)C3C(N2C(C)=NC=1C1C=CC=CC=1)=CC=CC=3)CCC>>[CH2:24]([N:20]([CH2:21][CH3:23])[CH2:19][CH2:18][C:8]1[C:7]2[C:11](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:10]2[C:12]([CH3:17])=[N:13][CH:14]=[C:15]([CH3:16])[C:9]=12)[CH3:25]Participants
Procedure
Similarly, by replacing 5-(2-chloroethyl)-1,4-dimethylpyrimido-[1,6-a]indole with an equivalent amount of another compound of formula 1 described in Example 12 and using N-methyl-N-(1-methylethyl)amine, the following compounds of formula 1 are obtained, respectively; 9-ethyl-1,4,N-trimethyl-N-(1-methylethyl)pyrimido[1,6-a]indole-5-ethanamine, 8-methoxy-1,4,N-trimethyl-N-(1-methylethyl)pyrimido[1,6-a]indole-5-ethanamine,7-phenylmethoxy-1,4,N-trimethyl-N-(1-methylethyl)pyrimido-[1,6-a]indole-5-ethanamine,1,N-dimethyl-N-(1-methylethyl)-4-propylpyrimido[1,6-a]indole-5-ethanamine,3,4-diethyl-1,N-dimethyl-N-(1-methylethyl)pyrimido[1,6-a]indole-5-ethanamine,1,4-diethyl-N-methyl-N-(1-methylethyl)-3-phenylpyrimido[1,6-a]indole-5-ethanamine, and 4-butyl-1,N-dimethyl-N-(1-methylethyl)-3-phenylpyrimido[1,6-a]indole-5-ethanamine.
Sources & evidence
- ORD record
- ord-c01393762132413bb92001c5cffbb9f9
- Source dataset
- uspto-grants-1981_12
- Patent number
- US04307234
Reaction notes
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