Lithium Hydroxide → Phosphinecarboxylic acid, dihydroxy-, phenyl ester, oxide

HRID 1660481Notes

Reaction equation

HRID 1660481 reaction equation
[C:1]1([O:7][C:8]([P:10]([O:16]OCC)([O:12]OCC)=[O:11])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Li+]>C(#N)C.C[Si](C)(C)Br>[C:1]1([O:7][C:8]([P:10]([OH:16])([OH:12])=[O:11])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 53852794HCID 53852794, compound

Product 1

HCID 511881Phosphinecarboxylic acid, dihydroxy-, phenyl ester, oxide

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 76113BromotrimethylsilaneSolvent

Procedure

25.8 parts by weight of diethoxyphosphonoformic acid phenyl ester are dissolved in 80 parts by volume of acetonitrile, and 36.7 parts by weight of trimethylbromosilane are added at 20° C. The mixture is stirred at 40°-45° C. for 2 hours and the solution is then evaporated in vacuo. The evaporation residue is taken up in 60 parts by volume of water and, after separating off the hexamethyldisiloxane formed, the resulting solution is neutralised with dilute lithium hydroxide solution and then evaporated in vacuo.

Workup

  1. additionare added at 20° C
  2. customthe solution is then evaporated in vacuo
  3. customafter separating off the hexamethyldisiloxane
  4. customformed
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-12b15c723a684c07bb5cb9b99eb251b5
Source dataset
uspto-grants-1981_12
Patent number
US04308263

Reaction notes

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