Propionic Acid → HCID 13018769, compound

HRID 1660515Notes

Reaction equation

HRID 1660515 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[NH2:9][CH2:10][CH2:11][CH2:12]O.[C:14]([OH:18])(=O)[CH2:15][CH3:16]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][CH2:11][CH2:10][NH:9][C:14](=[O:18])[CH2:15][CH3:16])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 90863-Amino-1-propanolHCID 660494-Bromothiophenol

Product 1

HCID 13018769HCID 13018769, compound

Procedure

The experiment of Example 1A was repeated in all essential details except that p-bromobenzenethiol, 3-aminopropanol and propionic acid are the reactants. There is obtained N-[3-(p-bromophenylthio)propyl]propionamide, m.p. 64°-65.5°. The nmr spectrum was consistent with the proposed structure. The compound, which was designated P-2172, was ineffective against eight species of bacterium and one species of fungi (Candida albicans), but the MIC for three species of fungi was 50-1000 and is thus effective for controlling their growth.

Sources & evidence

ORD record
ord-78c6e0cae7374690b20722537cf5f2a3
Source dataset
uspto-grants-1981_12
Patent number
US04308283

Reaction notes

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