Ammonia → HCID 86738183, compound

HRID 1660528Notes

Reaction equation

HRID 1660528 reaction equation
I.[CH2:2]([S:4][C:5]1[NH:6][C@@H:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:9]=1)[CH3:3].N>C(OCC)(=O)C.O>[CH2:2]([S:4][C:5]1[NH:9][C@@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C@H:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 86738182HCID 86738182, compound

Product 1

HCID 86738183HCID 86738183, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

25 ml of methanol and 1.85 g of ethyl iodide are added to 2.5 g of DL-trans-4,5-diphenyl-imidazolidine-2-thione and the mixture is refluxed for 15 hours. A further 0.4 g of ethyl iodide is then added and the mixture is refluxed for a further 5 hours. It is then evaporated to dryness. DL-trans-2-Ethylthio-4,5-diphenyl-imidazoline hydroiodide is obtained. In order to convert it to the base, this hydroiodide is suspended in 100 ml of ethyl acetate and 100 ml of water, the suspension is rendered alkaline with concentrated aqueous ammonia solution and the organic phase is separated off, dried over sodium sulfate and evaporated. DL-trans-2-Ethylthio-4,5-diphenyl-imidazoline with a melting point of 130°-132° is obtained.

Workup

  1. customthe organic phase is separated off
  2. dry with materialdried over sodium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-fdd13518125749cc951a90dc6f57de6c
Source dataset
uspto-grants-1981_12
Patent number
US04308277

Reaction notes

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