反应详情

A second composition to cover the perforated coated cores is prepared as follows: carisoprodol, diclofenac sodium, a diluent and a hinder are placed in a high shear mixer and mix for 5 minutes. The granulation process is initiated by the gradual addition of a granulating solution containing a plasticizer and purified water to the high shear with continuous blending to produce a wet blend. Next, the wet blend is granulated and dried at 40-500 for 20 minutes in a fluid bed to remove the water. Then, the dry granules are screened through a 20 USP mesh screen for size reduction. Next, the screened granules are mixed with a glidant and a lubricant, that have been previously passed through a 60 mesh screen, in a V-Blender during 5 minutes. The granulate is applied over the perforated cores through compression to obtain carisoprodol-diclofenac coated osmotic devices. The coated device has an outer diameter of about 14 mm.

1. customis prepared
2. additionmix for 5 minutes
3. additionThe granulation process is initiated by the gradual addition of a granulating solution
4. additioncontaining a plasticizer
5. custompurified water to the high shear with continuous blending
6. customto produce a wet blend
7. customdried at 40-500 for 20 minutes in a fluid bed
8. customto remove the water
9. additionNext, the screened granules are mixed with a glidant