Phosphoric Acid → HCID 25056268, compound

HRID 1660769Notes

Reaction equation

HRID 1660769 reaction equation
[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:5].[P:29](=[O:33])([OH:32])([OH:31])[OH:30]>CC(O)C>[P:29]([OH:33])([OH:32])([OH:31])=[O:30].[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:5]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 25022354Evogliptin

Product 1

HCID 25056268HCID 25056268, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

501 mg of the compound obtained in Example 11 was dissolved in 3 mL of 2-propanol, to which 84 μl of a 85% phosphoric acid aqueous solution was then slowly added followed by stirring for 30 min. 3 mL of 2-propanol was added thereto, and the resulting mixture was stirred for 10 min and filtered to afford 100 mg of the title compound as a solid.

Workup

  1. additionwas then slowly added
  2. stirringthe resulting mixture was stirred for 10 min
  3. filtrationfiltered

Sources & evidence

ORD record
ord-10160c3aae4147a9a44b7e0cdd0b7594
Source dataset
uspto-grants-2011_10
Patent number
US08030315B2

Reaction notes

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