Succinic Acid → HCID 25056528, compound

HRID 1660772Notes

Reaction equation

HRID 1660772 reaction equation
[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:5].[C:29]([OH:36])(=[O:35])[CH2:30][CH2:31][C:32]([OH:34])=[O:33]>CC(C)=O.CC(C)=O.O>[C:29]([OH:36])(=[O:35])[CH2:30][CH2:31][C:32]([OH:34])=[O:33].[NH2:1][C@H:2]([CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[F:28])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C:8](=[O:12])[C@H:7]1[CH2:13][O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:5]

Participants

5

Reactant 2

HCID 1110Succinic AcidHCID 25022354Evogliptin

Product 1

HCID 25056528HCID 25056528, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

498 mg of the compound obtained in Example 11 was dissolved in 3 mL of acetone to which a solution of 147 mg of succinic acid in 2 mL of acetone/water (20/1(v/v)) was then slowly added followed by stirring for 30 min. The reaction mixture was concentrated to dryness under reduced pressure to afford 596 mg of the title compound as a solid.

Workup

  1. additionwas then slowly added
  2. concentrationThe reaction mixture was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-16cd98bd1838462695072ee019017a26
Source dataset
uspto-grants-2011_10
Patent number
US08030315B2

Reaction notes

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