反应详情

温度

60 °C

A mixture of tetrahydropyran-4-yl-carboxylic acid (910 mg, 6.99 mmol) and SOCl2 (5.0 mL) was stirred for 1 h at 60° C. and concentrated in vacuo. To the residue were added benzyl alcohol (1.52 g, 14.1 mmol) and tetrahydrofuran (5.0 mL) at ambient temperature. The resulting mixture was stirred for 13 h at ambient temperature and concentrated in vacuo. The residue was purified by preparative thin layer chromatography (silica gel, eluting with hexane/ethyl acetate (2:1)) to give 1.08 g (70%) of the title compound as a pale yellow oil.

1. concentrationconcentrated in vacuo
2. stirringThe resulting mixture was stirred for 13 h at ambient temperature
3. concentrationconcentrated in vacuo
4. customThe residue was purified by preparative thin layer chromatography (silica gel, eluting with hexane/ethyl acetate (2:1))