Potassium Hydroxide → HCID 66788844, compound

HRID 1660849Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:15]=[C:14]2[C:9]([O:10][CH2:11][CH2:12][N:13]2[S:16]([C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[O:26][CH3:27])(=[O:18])=[O:17])=[N:8][CH:7]=1)=[O:5])C.[OH-].[K+:29]>O1CCCC1>[K+:29].[Cl:25][C:23]1[CH:22]=[CH:21][C:20]([O:26][CH3:27])=[C:19]([S:16]([N:13]2[C:14]3[C:9](=[N:8][CH:7]=[C:6]([C:4]([O-:5])=[O:3])[CH:15]=3)[O:10][CH2:11][CH2:12]2)(=[O:17])=[O:18])[CH:24]=1

Participants

Conditions

Temperature: 50 °C

Procedure

A mixture of 1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-4-oxa-1,5-diaza-naphthalene-7-carboxylic acid ethyl ester (124 mg, 0.30 mmol) in tetrahydrofuran (0.6 mL) and 1 M aq. potassium hydroxide solution (0.60 mL, 0.60 mmol) was stirred at 50° C. over 72 h. Evaporation of volatile material furnished 1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-4-oxa-1,5-diaza-naphthalene-7-carboxylic acid potassium salt (116 mg), which was directly used in the next step. Light yellow solid, MS (ISP)=383.1 (M−K)−.

Workup

customEvaporation of volatile material

Sources & evidence

ORD record: ord-fa71531e303943daac79016af524cc77
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08030308B2

Reaction notes

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