Thionyl Chloride → HCID 10702456, compound

HRID 1660908Notes

Reaction equation

HRID 1660908 reaction equation
[F:1][C:2]1[N:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:14])=O>C(Cl)Cl>[F:1][C:2]1[N:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:14])=[O:5]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 105830702,6-Difluoropyridine-3-carboxylic acid

Product 1

HCID 10702456HCID 10702456, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2,6-difluoronicotinic acid (6.2 g), thionyl chloride (15 mL) and CH2Cl2 (100 mL) was heated to reflux for 3 h. The mixture was evaporated to dryness, CH2Cl2, was added and evaporated to dryness to afford 1.1 g of the 2,6-difluoronicotinic acid chloride. This material used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 h
  3. customThe mixture was evaporated to dryness, CH2Cl2
  4. additionwas added
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-41e9e743c4694a59950552fb57e6b8df
Source dataset
uspto-grants-2011_10
Patent number
US08030318B2

Reaction notes

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