N,N-Dimethylethylenediamine → HCID 178483739, compound

Participants

Reaction Steps

To a solution of 2-(5-chloro-2-fluoro-phenyl)-7-fluoro-pyrido[2,3-d]pyrimidin-4-ol (0.16 g) in iso-propanol (20 mL) was added 2-dimethylamino-ethylamine (0.051 g). The mixture was heated to reflux for 1 h and the mixture was reduced in volume to afford a precipitate that was filtered and dried. The isolated solid, 2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido[2,3-d]pyrimidin-4-ol, was used without further purification.

Provenance & Evidence