N,N-Dimethylethylenediamine → HCID 178483739, compound

HRID 1660910Notes

Reaction equation

HRID 1660910 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:20])=[C:6]([C:8]2[N:9]=[C:10]([OH:19])[C:11]3[CH:17]=[CH:16][C:15](F)=[N:14][C:12]=3[N:13]=2)[CH:7]=1.[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH2:25]>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:20])=[C:6]([C:8]2[N:9]=[C:10]([OH:19])[C:11]3[CH:17]=[CH:16][C:15]([NH:25][CH2:24][CH2:23][N:22]([CH3:26])[CH3:21])=[N:14][C:12]=3[N:13]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 178517512HCID 178517512, compound

Product 1

HCID 178483739HCID 178483739, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 2-(5-chloro-2-fluoro-phenyl)-7-fluoro-pyrido[2,3-d]pyrimidin-4-ol (0.16 g) in iso-propanol (20 mL) was added 2-dimethylamino-ethylamine (0.051 g). The mixture was heated to reflux for 1 h and the mixture was reduced in volume to afford a precipitate that was filtered and dried. The isolated solid, 2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido[2,3-d]pyrimidin-4-ol, was used without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 h
  3. customto afford a precipitate that
  4. filtrationwas filtered
  5. customdried
  6. customThe isolated solid, 2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido[2,3-d]pyrimidin-4-ol, was used without further purification

Sources & evidence

ORD record
ord-57e6701803fd42ceb5908f6393986ade
Source dataset
uspto-grants-2011_10
Patent number
US08030318B2

Reaction notes

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