(3-Bromophenyl)boronic acid → HCID 59864214, compound

HRID 1660942Notes

Reaction equation

HRID 1660942 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([NH:14]C(NC3C=CC(OC4C=CN=C(NCCCCN(C)C)N=4)=CC=3C)=O)=[CH:10][C:9]=2[C:40]([F:43])([F:42])[F:41])[CH:5]=[CH:6][CH:7]=1.[Br:44]C1C=C(B(O)O)C=CC=1>CCCCCC.CCOC(C)=O>[Br:44][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=2[C:40]([F:43])([F:42])[F:41])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 59864171HCID 59864171, compound

Product 1

HCID 59864214HCID 59864214, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound is prepared as described in Ex. 3 (Step 3.1) for 1-(3′-chloro-2-trifluoromethyl-biphenyl-4-yl)-3-{4-[2-(4-dimethylamino-butylamino)-pyrimidin-4-yloxy]-2-methyl-phenyl}-urea but using 3-bromophenylboronic acid (Aldrich). The title compound: MS: 315.9 [M-1]−; HPLC DtRet=4.9; Rf=0.16 (Hexane/EtOAc, 4:1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-d6c2e87c82af41bab997d3843bbcf533
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

Loading…