(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid → HCID 11993479, compound

HRID 1660944Notes

Reaction equation

HRID 1660944 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[CH2:20]([N:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][C:30]=2[C:36]([F:39])([F:38])[F:37])[CH2:24][CH2:23]1)[CH3:21]>C(Cl)Cl.CO>[CH2:20]([N:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([NH:35][C:17](=[O:19])[CH2:16][C:13]3[CH:12]=[CH:11][C:10]([N:3]4[C:4]5=[N:5][CH:6]=[CH:7][CH:8]=[C:9]5[N:1]=[CH:2]4)=[CH:15][CH:14]=3)=[CH:31][C:30]=2[C:36]([F:39])([F:37])[F:38])[CH2:24][CH2:23]1)[CH3:21]

Participants

4

Reactant 2

HCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acidHCID 591345644-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline

Product 1

HCID 11993479HCID 11993479, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 7.1) and 4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (see WO 03/099771). Title compound: ES-MS: 523.0 [M+H]+; single peak at tR=3.00 min (System 1); Rf=0.12 (CH2Cl2/MeOH+1% NH3aq, 95:5).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-7513db0da8ca46739a9f85c81d3462a9
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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