4-Iodo-3-(trifluoromethyl)aniline → 2-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(4-iodo-3-trifluoromethyl-phenyl)-acetamide

HRID 1660947Notes

Reaction equation

HRID 1660947 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[I:20][C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][C:22]=1[C:28]([F:31])([F:30])[F:29]>C(Cl)Cl.CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:27][C:24]3[CH:25]=[CH:26][C:21]([I:20])=[C:22]([C:28]([F:31])([F:29])[F:30])[CH:23]=3)=[O:19])=[CH:14][CH:15]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 230036244-Iodo-3-(trifluoromethyl)anilineHCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid

Product 1

HCID 119935762-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(4-iodo-3-trifluoromethyl-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 7.1) and 4-iodo-3-trifluoromethyl-phenylamine. Title compound: ES-MS: 522.7 [M+H]+; single peak at tR=4.72 min (System 1); Rf=0.25 (CH2Cl2/MeOH, 95:5).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-3ca40e8b3d5b411f805b271fba3d73eb
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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