(4-Methoxyphenyl)boronic acid → HCID 131729209, compound

HRID 1660951Notes

Reaction equation

HRID 1660951 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[C:6](Br)[CH:7]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>CCCCCC.CCOC(C)=O>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:6]2[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=[C:2]([NH2:1])[CH:7]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 27358803-Bromo-5-(trifluoromethyl)aniline

Product 1

HCID 131729209HCID 131729209, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound is prepared as described in Example 13 but using 3-amino-5-bromobenzotrifluoride (RYAN SCIENTIFIC) and 4-methoxyphenylboronic acid (Aldrich). Title compound: ES-MS: 266.0 [M-H]−; single peak at tR=4.61 min (System 1); Rf=0.20 (Hexane/EtOAc, 3:1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-7dea5d4e3d6f4941ba3b47c1e1d59f11
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

Loading…