HCID 67021390, compound → HCID 67021578, compound

HRID 1660982Notes

Reaction equation

HRID 1660982 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[C:19]([N+:20]([O-])=O)=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:9][CH:8]=1)=[O:6])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:23])[C:5]([C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]2[C:19]([NH2:20])=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:11][CH:12]=1)=[O:6])[CH3:2]

Participants

4

Reactant 1

HCID 67021390HCID 67021390, compound

Product 1

HCID 67021578HCID 67021578, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd/C (9 mg) is added to a solution of [4-(3-nitro-pyridin-2-ylamino)-phenyl]oxo-acetic acid ethyl ester (26 7 mg, 0.847 mmol) in ethanol (2 mL). The mixture is stirred at rt for 1.5 h under H2. The reaction mixture is filtered through celite and the solvent removed under vacuum to afford [4-(3-amino-pyridin-2-ylamino)-phenyl]oxo-acetic acid ethyl ester as a yellow solid. Title compound: ES-MS: 286.10 [M+H]+; tR=0.9 min (System 2).

Workup

  1. filtrationThe reaction mixture is filtered through celite
  2. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-4319452192c54ad5bebf2f042ee6bf87
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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