Ethyl 4-nitrophenylglyoxylate → HCID 20525885, compound

HRID 1660984Notes

Reaction equation

HRID 1660984 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)=[O:6])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1)=[O:6])[CH3:2]

Participants

4

Reactant 1

HCID 522372Ethyl 4-nitrophenylglyoxylate

Product 1

HCID 20525885HCID 20525885, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (4-nitro-phenyl)-oxo-acetic acid ethyl ester (500 mg, 2.2 mmol) and 10% Pd/C (233 mg) in ethanol (2 mL) is stirred for 11 h under hydrogen. The reaction mixture is filtered through celite and concentrated. The yellow solid (4-amino-phenyl)-oxo-acetic acid ethyl ester is obtained. Title compound: tR=1.1 min (System 2).

Workup

  1. filtrationThe reaction mixture is filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-bb6976044af24c4a8864a9b48b0b5fae
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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