HRID1661014

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57431445

4-[[4-(1-Methylethyl)-1-piperazinyl]methyl]-3-(trifluoromethyl)benzenamine

C15H22F3N3

结构：O=C(O)Cc1c(Cl)cc(-n2cnc3cccnc32)cc1Cl

HCID67021568

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCN(Cc2ccc(NC(=O)Cc3c(Cl)cc(-n4cnc5cccnc54)cc3Cl)cc2C(F)(F)F)CC1

HCID67431164

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound is prepared as described in Example 7 but using (2,6-dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid and 4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (WO 03/099771). Title compound: ES-MS: 604.9/606.9 [M+H]+; tR=3.89 min (System 1); Rf=0.23 (CH2Cl2/(2N NH3 in MeOH), 95:5).

WORKUP

后处理

customThe title compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98a9fbf6ff7145ef826324fc7ed9b565
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030311B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[C:4]([Cl:17])[C:3]=1[CH2:18][C:19](O)=[O:20].[CH:22]([N:25]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([NH2:38])=[CH:34][C:33]=2[C:39]([F:42])([F:41])[F:40])[CH2:27][CH2:26]1)([CH3:24])[CH3:23]>C(Cl)Cl>[Cl:17][C:4]1[CH:5]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:18][C:19]([NH:38][C:35]1[CH:36]=[CH:37][C:32]([CH2:31][N:28]2[CH2:27][CH2:26][N:25]([CH:22]([CH3:24])[CH3:23])[CH2:30][CH2:29]2)=[C:33]([C:39]([F:42])([F:41])[F:40])[CH:34]=1)=[O:20]