HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline → 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline | HCID 57431445 | — |
| Reactant | (2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid | HCID 67021568 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide | HCID 67431164 | — |
Reaction Steps
The title compound is prepared as described in Example 7 but using (2,6-dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid and 4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (WO 03/099771). Title compound: ES-MS: 604.9/606.9 [M+H]+; tR=3.89 min (System 1); Rf=0.23 (CH2Cl2/(2N NH3 in MeOH), 95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030311B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-98a9fbf6ff7145ef826324fc7ed9b565 |
| Source note | uspto-grants-2011_10 |