3-(Trifluoromethyl)aniline → 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(3-trifluoromethyl-phenyl)-acetamide

HRID 1661021Notes

Reaction equation

HRID 1661021 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[C:4]([Cl:17])[C:3]=1[CH2:18][C:19](O)=[O:20].[F:22][C:23]([F:32])([F:31])[C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)[NH2:27]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[C:4]([Cl:17])[C:3]=1[CH2:18][C:19]([NH:27][C:26]1[CH:28]=[CH:29][CH:30]=[C:24]([C:23]([F:22])([F:31])[F:32])[CH:25]=1)=[O:20]

Participants

4

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 67021568(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid

Product 1

HCID 670215622-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(3-trifluoromethyl-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared as described in Example 7 but using (2,6-dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid (Step 56.1) and 3-(trifluoromethyl)aniline. Title compound: ES-MS: 462.9/464.9 [M-H]−; tR=5.08 min (System 1); Rf=0.37 (CH2Cl2/(2N NH3 in MeOH), 95:5).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-51e83efadc9049ecb7b39d1940a4cced
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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