HCID 59864195, compound → 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(4-diethylaminomethyl-3-trifluoromethyl-phenyl)-acetamide

HRID 1661022Notes

Reaction equation

HRID 1661022 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[C:4]([Cl:17])[C:3]=1[CH2:18][C:19](O)=[O:20].[CH2:22]([N:24]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][C:29]=1[C:35]([F:38])([F:37])[F:36])[CH2:25][CH3:26])[CH3:23]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[C:4]([Cl:17])[C:3]=1[CH2:18][C:19]([NH:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][N:24]([CH2:22][CH3:23])[CH2:25][CH3:26])=[C:29]([C:35]([F:36])([F:37])[F:38])[CH:30]=1)=[O:20]

Participants

4

Reactant 2

HCID 59864195HCID 59864195, compoundHCID 67021568(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid

Product 1

HCID 670213182-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(4-diethylaminomethyl-3-trifluoromethyl-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 7 but using (2,6-dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 56.1) and 4-diethylaminomethyl-3-trifluoromethyl-phenylamine (disclosed in WO2005/051366). Title compound: ES-MS: 549.9/551.9 [M+H]+; tR=3.93 min (System 1); Rf=0.28 (CH2Cl2/MeOH, 95:5+0.1% NH3aq).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-265c2d2fb37842db8479b67c25849f47
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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