HCID 59864195, compound → N-(4-Diethylaminomethyl-3-trifluoromethyl-phenyl)-2-(4-imidazo[4,5-b]pyridin-3-yl-2-methyl-Phenyl)-acetamide

HRID 1661023Notes

Reaction equation

HRID 1661023 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1.[CH2:21]([N:23]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][C:28]=1[C:34]([F:37])([F:36])[F:35])[CH2:24][CH3:25])[CH3:22]>C(Cl)Cl.CO>[CH2:21]([N:23]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:17](=[O:19])[CH2:16][C:13]2[CH:14]=[CH:15][C:10]([N:3]3[C:4]4=[N:5][CH:6]=[CH:7][CH:8]=[C:9]4[N:1]=[CH:2]3)=[CH:11][C:12]=2[CH3:20])=[CH:29][C:28]=1[C:34]([F:35])([F:36])[F:37])[CH2:24][CH3:25])[CH3:22]

Participants

4

Reactant 2

HCID 59864195HCID 59864195, compoundHCID 67021622(4-Imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid

Product 1

HCID 67021612N-(4-Diethylaminomethyl-3-trifluoromethyl-phenyl)-2-(4-imidazo[4,5-b]pyridin-3-yl-2-methyl-Phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 7 but using (4-imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid and 4-diethylaminomethyl-3-trifluoromethyl-phenylamine (disclosed in WO2005/051366). Title compound: ES-MS: 496.0 [M+H]+; tR=3.31 min (System 1); Rf=0.43 (CH2Cl2/MeOH, 95:5+0.1% NH3aq).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-527c41e1d4f7417f8f6748b3c10e2496
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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