HRID1661027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID46838908

4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline

C13H18F3N3

HCID67021622

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)Nc1ccc(CN2CCN(C)CC2)c(C(F)(F)F)c1

HCID67021656

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as described in Example 7 but using (4-imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid (Step 60.1) and 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (disclosed in WO 03/099771). Title compound: ES-MS: 523.0 [M+H]+; tR=3.11 min (System 1); Rf=0.18 (CH2Cl2/MeOH, 95:5+0.1% NH3aq).

WORKUP

后处理

customThe title compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c2cd1cce6a8a49669e5799f9053115af
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030311B2
来源说明: uspto-grants-2011_10

反应 SMILES

[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1.[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][C:30]=2[C:36]([F:39])([F:38])[F:37])[CH2:24][CH2:23]1>C(Cl)Cl.CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([NH:35][C:32]3[CH:33]=[CH:34][C:29]([CH2:28][N:25]4[CH2:24][CH2:23][N:22]([CH3:21])[CH2:27][CH2:26]4)=[C:30]([C:36]([F:39])([F:38])[F:37])[CH:31]=3)=[O:19])=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1