4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline → N-[4-(4-Isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2-(4-purin-9-yl-phenyl)-acetamide

HRID 1661033Notes

Reaction equation

HRID 1661033 reaction equation
[N:1]1[CH:9]=[C:8]2[C:4]([N:5]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=3)[CH:6]=[N:7]2)=[N:3][CH:2]=1.[CH:20]([N:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][C:31]=2[C:37]([F:40])([F:39])[F:38])[CH2:25][CH2:24]1)([CH3:22])[CH3:21]>C(Cl)Cl.CO>[CH:20]([N:23]1[CH2:24][CH2:25][N:26]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([NH:36][C:17](=[O:19])[CH2:16][C:13]3[CH:12]=[CH:11][C:10]([N:5]4[CH:6]=[N:7][C:8]5[C:4]4=[N:3][CH:2]=[N:1][CH:9]=5)=[CH:15][CH:14]=3)=[CH:32][C:31]=2[C:37]([F:40])([F:39])[F:38])[CH2:27][CH2:28]1)([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 574314454-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-anilineHCID 67021576(4-Purin-9-yl-phenyl)-acetic acid

Product 1

HCID 67021696N-[4-(4-Isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2-(4-purin-9-yl-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-purin-9-yl-phenyl)-acetic acid and 4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (disclosed in WO 03/099771). Title compound: ES-MS: 538.1 [M+H]+; tR=2.93 min (System 1); Rf=0.12 (CH2Cl2/MeOH/NH3aq, 94:5:1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-454f5ade0195492ab7d19fac810c6c94
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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