HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline → N-[4-(4-Isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2-(4-purin-9-yl-phenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline | HCID 57431445 | — |
| Reactant | (4-Purin-9-yl-phenyl)-acetic acid | HCID 67021576 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | N-[4-(4-Isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2-(4-purin-9-yl-phenyl)-acetamide | HCID 67021696 | — |
Reaction Steps
The title compound is prepared as described in Example 1 but using (4-purin-9-yl-phenyl)-acetic acid and 4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (disclosed in WO 03/099771). Title compound: ES-MS: 538.1 [M+H]+; tR=2.93 min (System 1); Rf=0.12 (CH2Cl2/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030311B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-454f5ade0195492ab7d19fac810c6c94 |
| Source note | uspto-grants-2011_10 |