Tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-carboxylate → 5-Chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine] hydrochloride

HRID 1661051Notes

Reaction equation

HRID 1661051 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:19](=[CH:20][CH:21]=1)[C:7]1([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)[CH2:6][CH2:5]2>CO.Cl.CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:19](=[CH:20][CH:21]=1)[C:7]1([CH2:11][CH2:10][NH:9][CH2:8]1)[CH2:6][CH2:5]2

Participants

4

Reactant 1

HCID 59233931Tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-carboxylate

Product 1

HCID 674279925-Chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine] hydrochlorideYield 82%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21893726Hydrochloride methanolSolvent

Procedure

To a solution of tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3′-pyrrolidine]-1′-carboxylate (Prep9, 900 mg, 2.93 mol) in methanol (10 ml), HCl/CH3OH (10 ml, 3M in methanol) was added and stirred overnight at room temperature. The solvent was evaporated in vacuo to give the title compound (500 mg, y=82%).

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-838b1bcb237f480db3aedb28511e90ef
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

Loading…