HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-carboxylate → 5-Chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine] hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-carboxylate | HCID 59233931 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Hydrochloride methanol | HCID 21893726 | — |
| Product | 5-Chloro-2,3-dihydrospiro[indene-1,3'-pyrrolidine] hydrochloride | HCID 67427992 | 82% |
Reaction Steps
To a solution of tert-butyl 5-chloro-2,3-dihydrospiro[indene-1,3′-pyrrolidine]-1′-carboxylate (Prep9, 900 mg, 2.93 mol) in methanol (10 ml), HCl/CH3OH (10 ml, 3M in methanol) was added and stirred overnight at room temperature. The solvent was evaporated in vacuo to give the title compound (500 mg, y=82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030322B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-838b1bcb237f480db3aedb28511e90ef |
| Source note | uspto-grants-2011_10 |