Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | (E)-ethyl 2-cyano-2-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate | HCID 68217618 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59233922 | HCID 59233922 | — |
Reaction Steps
To a solution of (E)-ethyl 2-cyano-2-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate (Prep11, 100 g, 0.408 mol) in ethanol (800 ml) a solution of KCN (67 g, 1.02 mol) in water (240 ml) was added, and warmed to 65° C. The mixture was stirred for 24 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08030322B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-35ff988006ea4ae28372a3eba89ff579 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
