Potassium Cyanide → HCID 59233922, compound

HRID 1661053Notes

Reaction equation

HRID 1661053 reaction equation
[C:1](/[C:3](=[C:9]1/[CH2:10][CH2:11][C:12]2[C:17]/1=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)/C(OCC)=O)#[N:2].[C-:19]#[N:20].[K+]>C(O)C.O>[C:1]([CH2:3][C:9]1([C:19]#[N:20])[C:17]2[C:12](=[CH:13][C:14]([F:18])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)#[N:2]

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 68217618HCID 68217618, compound

Product 1

HCID 59233922HCID 59233922, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of (E)-ethyl 2-cyano-2-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate (Prep11, 100 g, 0.408 mol) in ethanol (800 ml) a solution of KCN (67 g, 1.02 mol) in water (240 ml) was added, and warmed to 65° C. The mixture was stirred for 24 h.

Sources & evidence

ORD record
ord-35ff988006ea4ae28372a3eba89ff579
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

Loading…