反应详情

A solution of 3-(3-chloro-4-methoxyphenyl)propanoic acid (10 g, 46.7 mmol, commercially available) in PPA (100 mL) was stirred for 2 h at 70 C. Water was added to the mixture and extracted with EA twice. The organic phase were combined and dried over anhydrous Na2SO4, concentrated, purified by FC to afford 6 g of the title compound (y=66%).

1. extractionextracted with EA twice
2. dry with materialdried over anhydrous Na2SO4
3. concentrationconcentrated
4. custompurified by FC