3-(3-chloro-4-methoxyphenyl)propanoic acid → 5-Chloro-6-methoxy-1-indanone

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Reaction Steps

A solution of 3-(3-chloro-4-methoxyphenyl)propanoic acid (10 g, 46.7 mmol, commercially available) in PPA (100 mL) was stirred for 2 h at 70 C. Water was added to the mixture and extracted with EA twice. The organic phase were combined and dried over anhydrous Na2SO4, concentrated, purified by FC to afford 6 g of the title compound (y=66%).

Provenance & Evidence