Hydrazine hydrate (1:1) → 2,4-Dimethylthiazole-5-carbohydrazide

Participants

Reaction Conditions

Reaction Steps

To ethyl 2,4-dimethylthiazole-5-carboxylate (Prep25, 50 g, 0.27 mol) in ethanol (200 mL), hydrazine hydrate (64 g, 1.08 mol) was added. The mixture was stirred at 90° C. overnight. After cooling to room temperature, the solvent was removed under vacuum to afford 41 g of crude product as a solid. The crude was purified by FC to give 23 g pure title compound product (y=50%).

Provenance & Evidence