反应详情

温度

90 °C

To ethyl 2,4-dimethylthiazole-5-carboxylate (Prep25, 50 g, 0.27 mol) in ethanol (200 mL), hydrazine hydrate (64 g, 1.08 mol) was added. The mixture was stirred at 90° C. overnight. After cooling to room temperature, the solvent was removed under vacuum to afford 41 g of crude product as a solid. The crude was purified by FC to give 23 g pure title compound product (y=50%).

1. temperatureAfter cooling to room temperature
2. customthe solvent was removed under vacuum
3. customto afford 41 g of crude product as a solid
4. customThe crude was purified by FC