Methyl isothiocyanate → HCID 178432727, compound

HRID 1661063Notes

Reaction equation

HRID 1661063 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]([NH:10][NH2:11])=O)=[C:5]([CH3:7])[N:6]=1.[CH3:12][N:13]=[C:14]=[S:15]>C(O)C>[CH3:1][C:2]1[S:3][C:4]([C:8]2[N:13]([CH3:12])[C:14]([SH:15])=[N:11][N:10]=2)=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 27436692,4-Dimethylthiazole-5-carbohydrazide

Product 1

HCID 178432727HCID 178432727, compoundYield 47.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 2,4-dimethylthiazole-5-carbohydrazide (Prep26, 23 g, 0.13 mol) in ethanol (100 ml), methyl isothiocyanate (49.1 g, 0.67 mol) was added. The mixture was refluxed overnight. Then the ethanol was partially removed under vacuum and the residue was filtered. The solid was dried under vacuum to afford 14 g of the title compound (y=46%).

Workup

  1. temperatureThe mixture was refluxed overnight
  2. customThen the ethanol was partially removed under vacuum
  3. filtrationthe residue was filtered
  4. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-6a53f4a191fd4b9688199acb32574d83
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

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