HCID 59233917, compound → HCID 67427879, compound

HRID 1661068Notes

Reaction equation

HRID 1661068 reaction equation
[Cl:1][C:2]1[CH:21]=[C:20]2[C:5]([CH2:6][CH2:7][C:8]32[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]3)=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:21]=[C:20]2[C:5]([CH2:6][CH2:7][C:8]32[CH2:12][CH2:11][NH:10][CH2:9]3)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 59233917HCID 59233917, compound

Product 1

HCID 67427879HCID 67427879, compoundYield 181.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of tert-butyl 6-chloro-2,3-dihydrospiro[indene-1,3′-pyrrolidine]-1′-carboxylate (Prep42, 2.50 g, 8.14 mmol) in ether (50 ml), a 1N solution of hydrochloric acid-ether (50 ml) was added and stirred overnight. The mixture was washed by anhydrous ether. The residue was dissolved in DCM and concentrated to give the title compound (1.8 g, y=81.3%).

Workup

  1. washThe mixture was washed by anhydrous ether
  2. dissolutionThe residue was dissolved in DCM
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f7531eccac7a4dd1ab1d3139f4370166
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

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