3-Fluorobenzoyl chloride → HCID 3486255, compound

HRID 1661173Notes

Reaction equation

HRID 1661173 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].Cl.[C:12]1([C:18]2[N:22]=[C:21]([CH:23]3[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]3)[O:20][N:19]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)Cl.CO>[F:1][C:2]1[CH:3]=[C:4]([C:5]([N:25]2[CH2:26][CH2:27][CH2:28][CH:23]([C:21]3[O:20][N:19]=[C:18]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[N:22]=3)[CH2:24]2)=[O:6])[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 46737061HCID 46737061, compound

Product 1

HCID 3486255HCID 3486255, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The compound was prepared following the procedure described in the Example 3 (D), using 3-Fluoro-benzoyl chloride as the acyl chloride of choice and the 3-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride (already prepared before in the Example 7). Yield: 53% (yellow oil); Rf=0.25 (DCM/MeOH:98/2); LCMS (Tr): 4.77 min (Method C); MS (ES+) gave m/z: 352.3.

Workup

  1. customThe compound was prepared
  2. custom4.77 min (Method C)
  3. customMS (ES+) gave m/z

Sources & evidence

ORD record
ord-3c2f6cd4d0004a359ecb444191cc249d
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

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