反应详情

A suspension of 4-fluoro-N-methyl-benzamide (CAS: 701-49-5, 0.106 g, 0.69 mmol) in thionyl chloride (202 mL, 2.78 mmol) was refluxed for 1 h 30 min. The solvent was removed under reduced pressure, then toluene was added and the solvent was evaporated under reduced pressure to afford a yellow oil used immediately for the next step.

1. temperaturewas refluxed for 1 h 30 min
2. customThe solvent was removed under reduced pressure
3. additiontoluene was added
4. customthe solvent was evaporated under reduced pressure
5. customto afford a yellow oil