HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Fluoro-N-methyl-benzimidoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-fluoro-N-methylbenzamide | HCID 4074247 | — |
| Product | 4-Fluoro-N-methyl-benzimidoyl chloride | HCID 86615130 | — |
Reaction Steps
A suspension of 4-fluoro-N-methyl-benzamide (CAS: 701-49-5, 0.106 g, 0.69 mmol) in thionyl chloride (202 mL, 2.78 mmol) was refluxed for 1 h 30 min. The solvent was removed under reduced pressure, then toluene was added and the solvent was evaporated under reduced pressure to afford a yellow oil used immediately for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030331B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8da521fcb85f4c38a573e317438a015e |
| Source note | uspto-grants-2011_10 |