Hydrochloric Acid → HCID 66618331, compound

HRID 1661184Notes

Reaction equation

HRID 1661184 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[O:18][N:17]=[C:16]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[N:15]=2)[CH2:9]1)=O)(C)(C)C.[ClH:26]>ClCCl>[ClH:26].[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:16]2[N:15]=[C:14]([CH:10]3[O:11][CH2:12][CH2:13][NH:8][CH2:9]3)[O:18][N:17]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66618582HCID 66618582, compound

Product 1

HCID 66618331HCID 66618331, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[3-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-morpholine-4-carboxylic acid tert-butyl ester (0.325 g, 0.93 mmol) was dissolved in dichloromethane (3 mL) and 5 mL of HCl 4N (dioxane solution) were added dropwise. The resulting mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure to afford 265 mg (yield: 100%) of 2-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-morpholine hydrochloride as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-400ce75b9d514bc6a5def9e171be5c49
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

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