Hydrochloric Acid → HCID 66618243, compound

HRID 1661189Notes

Reaction equation

HRID 1661189 reaction equation
[ClH:1].C(O[C:7]([N:9]1[CH2:14][CH2:13][N:12](C)[CH2:11][CH:10]1[C:16]1[O:20][N:19]=[C:18]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[N:17]=1)=O)(C)(C)C>CO>[ClH:1].[ClH:1].[F:27][C:24]1[CH:25]=[CH:26][C:21]([C:18]2[N:17]=[C:16]([CH:10]3[CH2:11][NH:12][CH2:13][CH2:14][N:9]3[CH3:7])[O:20][N:19]=2)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86615131HCID 86615131, compound

Product 1

HCID 66618243HCID 66618243, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl 4N (3 mL dioxane solution) was dropped into a solution of -[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-4-methyl-piperazine-1-carboxylic acid tert-butyl ester (0.312 g, 0.86 mmol) in methanol (8 mL) and the solution was kept under stiffing overnight at R.T. Evaporation of the volatiles under reduced pressure provided 2-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-piperazine dihydrochloride as a white solid (0.285 g).

Workup

  1. customEvaporation of the volatiles under reduced pressure

Sources & evidence

ORD record
ord-4a3eb3a72f8c4f4ca15a58a0a8a721cc
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

Loading…